Oct.2023 10
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High-Throughput Technologies Focus

Introduction
A recently established contract manufacturer says that its lack of legacy equipment means the company can focus on installing high-throughput technologies. Wheeler Bio was founded as a COVID-19 laboratory to help the testing effort in Oklahoma during the pandemic. Then, in 2021, the company became a contract manufacturer.
Details
A recently established contract manufacturer says that its lack of legacy equipment means the company can focus on installing high-throughput technologies. Wheeler Bio was founded as a COVID-19 laboratory to help the testing effort in Oklahoma during the pandemic. Then, in 2021, the company became a contract manufacturer.

A recently established contract manufacturer says that its lack of legacy equipment means the company can focus on installing high-throughput technologies. Wheeler Bio was founded as a COVID-19 laboratory to help the testing effort in Oklahoma during the pandemic. Then, in 2021, the company became a contract manufacturer.

Data generators

Wheeler says it is using high-throughput technologies, such as the Sartorius Ambr® 15 cell culture system, to aid with their process development services. These systems generate a lot of data, explains Morgan. As such, the firm can do high-throughput analytics by running ELISAs on a below-deck plate reader beneath the Tecan RoboColumns they use for downstream purification.

The company, which aims to analyze multiple parameters simultaneously and hope, in the future, to automate most of every process, is also partnering with machine learning software company DataHow, which is helping them build a digital twin for upstream process development.

Going forward, Wheeler believes it will benefit from the multiple medical research institutes in Oklahoma, including the Stevenson Cancer Center.

“We like to emphasize [to our customers] that Oklahoma is a good place to test drugs in clinical trials as there are lots of clinics relative to the population density. We have a diverse population as well,” says Morgan, who spoke at the BioProcess International Conference  in September in Boston about accelerating method preparation to speed up development timelines.

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