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Liquid Biopsy ctDNA Could Serve as Early Marker of Immunotherapy Response
2023-10-10
Results from the first stage of a Phase II clinical trial suggest that measuring circulating tumor DNA (ctDNA) captured in blood-based liquid biopsies may help to identify those advanced non-small cell lung cancer (NSCLC) patients undergoing immunotherapy who could benefit from treatment with additional drugs. Data from this first stage of the international Phase II BR.36 study in the United States and Canada
Enhancing Automation in Making Cell Therapies
2023-10-10
Although many people could benefit from cell therapy, many can’t get it. “The entire industry is focused on ensuring safety while increasing accessibility,” says Evan Zynda, PhD, senior staff scientist at Thermo Fisher Scientific. “When it comes to developing and manufacturing cell therapies, the main challenges to these goals are manufacturing inefficiencies, complex and manual processes that require human intervention and introduce failure modes
BMS Expands Its Cancer Portfolio with Up-to-$5.8B Mirati Purchase
2023-10-10
Bristol Myers Squibb (BMS) has agreed to acquire Mirati Therapeutics for up to $5.8 billion, in a deal that expands the buyer’s cancer portfolio with Mirati’s marketed drug Krazati® (adagrasib) and several pipeline candidates that have shown positive albeit early clinical data. [Mirati Therapeutics]
AACR Cancer Progress Report Touts Advances, Advocates Continued Government Research Funding
2023-09-14
he American Association for Cancer Research (AACR) released its annual Cancer Progress Report on Wednesday that highlighted advances in cancer treatments and survival while also advocating for continued funding by the US government to sustain progress.
Swedish Researchers say AI Ready for Breast Cancer Detection in Clinic
2023-09-14
AI is ready for the clinic, say researchers from the Karolinska Institutet.  For over 30 years, screening mammography has been a key in reducing breast cancer mortality rates. However, challenges include a lack of radiologists and that not all cancers are detected. Numerous studies have looked at using AI in radiology to accelerate and improve breast cancer detection. This new study finds that a single radiologist using AI is more accurate than review by two radiologists.
New Tools in the Host Cell Protein Analysis Toolbox
2023-09-14
Mass spectrometry and electrochemiluminescence technologies may complement rather than obviate well-established ELISA-based methods
Novel Genetic Insights into Staphylococcus aureus Uncovered
2023-09-14
Staphylococcus aureus is a gram-positive bacteria that causes a wide variety of clinical diseases. Infections caused by this pathogen are common both in community-acquired and hospital-acquired settings. Infections can be life-threatening if the bacteria enter the bloodstream, causing sepsis. Now, researchers led by the Peter Doherty Institute for Infection and Immunity analyzed the genetic profiles of more than 1,300 staph strains and uncovered what makes the bacterium so dangerous when it ente
Urgency Is Needed to Drive Gene Therapy and Bioprocessing
2023-09-14
Looking forward, with urgency, to the focus on gene therapy at the BioProcess International meeting.GEN team that focus on the work going on in the bioprocessing field are heading to Boston for the second time in as many months.
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