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Genotoxic Effects by Base and Prime Editors in Human HSPCs Aren’t Surprising, Says Pioneer
2023-09-14
David Liu, PhD, isn’t troubled by the findings of a new Nature Biotechnology paper from Luigi Naldini’s lab reporting genotoxicity concerns, yet the blueprint and metrics described can instruct evaluation of emerging editing tools
Noncanonical Amino Acids Inspire the Development of Novel Drugs
2023-09-12
Commercial platforms for protein therapeutics are being built on academic research that has expanded the genetic code behind cell-based translation.
NGS Answers Ambitious Questions
2023-09-12
The cost of sequencing continues to decrease. Now is the right time to start using next-generation sequencing to answer your scientific questions and further your research goals. NGS provides the power to sequence vast amounts of genetic material at a fraction of the time and cost of traditional methods.1 As the cost continues to decrease, this technology has become a critical asset to scientists. Now is the right time to leverage this impartial approach to reveal a broader landscape of ...
Single-Cell Spatial Proteomics by Molecular Pixelation
2023-09-12
Pixelgen Technologies describes a DNA-based visualization technology for mapping cell surface proteins and their spatial interrelationships Flow cytometry using fluorophore-labeled antibodies has been extensively used to study proteins on immune cells for several decades. More recently, efforts have been made to overcome the multiplexing limitations of conventional flow cytometry by instead labeling antibodies with isotopes for mass spectrometry readout, or with oligonucleotides for next-...
CRISPR-Cas9 Alternatives: Cutting through the Boundaries of Gene Editing
2023-09-12
This GENcast is part 1 of a 3-part series on Cas-CLOVER, “the proven alternative to CRISPR-Cas9,” sponsored by Demeetra AgBio—exclusive Cas-CLOVER licensing partner for bioprocessing, synthetic biotechnology, and agriculture. Here I sat down with Dr. Eric Ostertag, MD, PhD, Executive Chairman at Poseida Therapeutics, and Harvard/MIT professor Dr. George Church, PhD, who leads synthetic biology at the Wyss Institute. A wealth of gene editing experience, stories, and applications are shared in ...
Improving Protein Therapeutic Production is a Key Goal of Biopharma 4.0
2023-09-12
Transformation is never a simple or fast process, especially in the biopharmaceutical industry. Yet, transformative events are integral to generating new therapeutics that have the potential to aid thousand or even millions of lives. Transformation in science can happen on many fronts, and Biopharma 4.0 was put into place to tackle the aging manufacturing process by applying new digital tools and data analytics to understand production workflows better and ensure greater product consistency,
Biomanufacturing’s 10-Year Plan for the Future
2023-09-12
Scientific collaborations exist in numerous forms, from small one-on-ones to large industry partnerships. Yet sometimes it’s difficult to know where to turn for the appropriate collaborative assistance, and investigators can be left to feel stranded. Thankfully, resources like BioPhorum have created an environment where the global biopharmaceutical industry can collaborate to accelerate their rate of progress for the benefit of all. In this new GENcast, we sit down with a panel of scientific ...
Biomanufacturing Melanin for Drug Delivery Applications
2023-09-12
Alternatively, bioprocessors can chemically synthesize melanin, but the best approach might come from microbes. As a team of scientists from India recently pointed out, “Current bioprocess technologies have paved [the way] for the large-scale or industrial production of microbial melanin, which could help in the replacement of synthetic melanin.” As one example, Zheng Wang, PhD, a research biologist at the U.S. Naval Research Laboratory, and his colleagues turned the bacteria Vibrio natriegens 
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