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Soft Sensors Support Real-Time, Autonomous Process Monitoring
2023-09-12
Batch processing and testing is a mainstay of the biopharmaceutical industry today. But, as operations become increasingly automated and continuous and integrated manufacturing is adapted more widely, the method of testing must change to produce biopharmaceuticals faster and more efficiently.
First Complete Genome Map of Ancient Wheat, Einkorn, Assembled
2023-09-12
The 5.2-billion-letter-long sequence provides a window into the evolutionary origins of different wheat species. In addition, it could help farmers and crop breeders with genomics-assisted improvement of einkorn and bread wheat—developing varieties with enhanced disease resistance, higher yields, and improved hardiness.
Engineered Proteins Take On Cancer’s Epigenome
2023-09-12
Part of what makes the epigenome an attractive target is the possibility of hitting a system of proteins involved in gene expression programming rather than a single target, according to Karmella Haynes, PhD, an assistant professor of biomedical engineering at Emory University. She and a team of scientists from Emory University and Georgia Institute of Technology have developed another potential approach for reactivating repressed tumor suppressor genes that could ultimately have implications
Perfect Pitch: Genome Editing Pioneer Fyodor Urnov on Commercializing CRISPR Therapies and Epigenomic Tuning
2023-09-12
In this episode of Close to the Edge from GEN, senior editor Jonathan D. Grinstein, PhD, speaks with Fyodor Urnov, PhD, a pioneer in the field of genome editing. Urnov is a professor of molecular and cell biology at UC Berkeley, the scientific director of technology and translation at the Innovative Genomics Institute in Berkeley, California, and a co-founder of Tune Therapeutics, one of several biotechs exploring epigenome editing.
New Indicators of Health, Disease, and Aging Unlocked by the Lipidome
2023-09-12
The sequencing of the human genome promised a revolution in medicine, but scientists soon realized that a genetic blueprint alone does not show the body in action. The lipidome may be filling out more details of human physiology that are not fully seen in the human genome. A new study from the lab of Michael Snyder, PhD, the Stanford W. Ascherman, MD, FACS professor in genetics, is among the first to deeply dive into the human lipidome and track how it changes under healthy and diseased conditio
Food For Thought: Final Report from the AGBT Ag Meeting
2023-09-12
After three terrific days in San Antonio, the second annual AGBT Ag meeting has come to a close. Right before heading to the airport, Julianna LeMieux, PhD, Deputy Editor in Chief at GEN spoke with Kevin Davies, PhD, GEN‘s Editor at Large, about some of what she learned over the past three days. Although this may have been LeMieux’s first rodeo in the agriculture world, the science going on there is too good to not explore further in the year ahead.
Celebrating DNA Day: An Interview with Eric Green on “The State of Genomics”
2023-09-12
Here at GEN, we could not think of a better way to celebrate DNA Day than to highlight a conversation with Eric Green, MD, PhD, director of the NHGRI, held earlier this year during “The State of Genomics and NGS Summit.” Green has been a key player in the field of genomics for decades. He held a pivotal role in the completion of the Human Genome Project and succeeded Francis Collins, MD, PhD, as head of NHGRI in 2009.
New Approach to Alzheimer’s Disease Treatment May Come from Exercise-Induced Hormone
2023-09-12
Researchers led by a team at Massachusetts General Hospital (MGH) used a 3D human cell culture model of Alzheimer’s disease (AD) to identify a cellular and molecular mechanism by which the exercise-induced muscle hormone, irisin, may prevent build up of the amyloid-beta (Aβ) deposits that are characteristic of AD pathology.
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